Alloantigenic Composition of the Endothelial Vitronectin Receptor
نویسنده
چکیده
Endothelial cells synthesize a heterodimeric adhesion molecule. the vitronectin receptor (VnR). which is similar to the platelet glycoprotein (GP)llb/IlIa complex. The subunits of the endothelial VnR (VnRa and GPIIIa) have been studied for their ability to express alloantigens associated with platelet GPIIb and lIla. We previously showed that endothehal GPIIIa can express the platelet alloantigen Zw or which is associated with GPllla. We studied the relationship between the expression of Zw on platelets and endothelial cells in neonates (n = 1 3). Using immunoprecipitation and immunofluorescence techniques. we showed that the Zw antigen is either expressed or absent from both platelets and endothelial cells of the same individual.
منابع مشابه
Alloantigenic composition of the endothelial vitronectin receptor.
Endothelial cells synthesize a heterodimeric adhesion molecule, the vitronectin receptor (VnR), which is similar to the platelet glycoprotein (GP)IIb/IIIa complex. The subunits of the endothelial VnR (VnR alpha and GPIIIa) have been studied for their ability to express alloantigens associated with platelet GPIIb and IIIa. We previously showed that endothelial GPIIIa can express the platelet all...
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